Collies may have a genetic disease, canine cyclic neutropenia, or Grey Collie Syndrome.
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Canine cyclic neutropenia is a cyclic blood disorder that is usually fatal to affected puppies.
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Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia ( SCN ).
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Other investigations commonly performed : serial neutrophil counts for suspected cyclic neutropenia, tests for vitamin B 12 and folate assays.
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Aphthous-like ulceration also occurs in conditions involving systemic immuno-dysregulation, e . g . cyclic neutropenia and human immunodeficiency virus infection.
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In cyclic neutropenia, more severe oral ulceration occurs during periods of severe immuno-dysregulation, and resolution of the underlying neutropenia prevents the cycle of ulceration.
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In cyclic neutropenia, there is a reduction in the level of circulating neutrophils in the blood that occurs about every 21 days . Opportunistic infections commonly occur and aphthous-like ulceration is worst during this time.
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